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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3043 | Ruxolitinib phosphate | INC424,INCB018424,INC 424 phosphate,Ruxolitinib (INCB-18424) phosphate,INCB018424 phosphate | Mitophagy , JAK , Autophagy |
Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. | |||
T2476 | INCB032304 | 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)-methyl)-7H-pyrrolo[2,3-d]pyrimidine | Others |
INCB032304 is an important pharmaceutical intermediate. It can be used in the preparation of Ruxolitinib phosphate (I008849), a janus kinase inhibitor, and in the preparation of Barretinib. |